Flutamide Induced Liver Injury in Female Patients
نویسندگان
چکیده
منابع مشابه
Metabolite profiles of flutamide in serum from patients with flutamide-induced hepatic dysfunction.
Hepatic dysfunction due to flutamide administration has been reported and this side effect often limits the use of the agent. The prediction of flutamide-induced hepatotoxicity is attributed to the proper use of the antiandrogen. In this study, we investigated whether hepatic dysfunction could be assessed by the metabolite profile in serum from patients receiving this drug. Serum samples were o...
متن کاملFlutamide-associated acute liver failure.
The nonsteroidal antiandrogenic drug flutamide [4'-nitro-3'-(trifluoromethyl)isobutyranilide] is a safe and generally well-tolerated drug used for the treatment of prostate cancer. We describe the case of a 74-year-old male who developed life-threatening acute liver failure during flutamide therapy. Other causes of acute liver failure were appropriately ruled out and there was no evidence of ac...
متن کاملFlutamide-induced hepatotoxicity
Abstract. – OBJECTIVE: Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer. While this indication limits the use to male patients, FLU is widely prescribed to women, off-label, for the treatment of polycystic ovary syndrome (POCS) related hirsutism and acne. According to the literature, its assumption is associated with a higher incidence ...
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Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. We recommend that clinicians should monitor liver function carefully following duloxetine treatment.
متن کاملSerum proteomic profiling in patients with drug-induced liver injury.
BACKGROUND Idiosyncratic drug-induced liver injury (DILI) is a complex disorder that is difficult to predict, diagnose and treat. AIM To describe the global serum proteome of patients with DILI and controls. METHODS A label-free, mass spectrometry-based quantitative proteomic approach was used to explore protein expression in serum samples from 74 DILI patients (collected within 14 days of ...
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ژورنال
عنوان ژورنال: European Journal of Medical and Health Sciences
سال: 2020
ISSN: 2593-8339
DOI: 10.24018/ejmed.2020.2.5.476